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Article

Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde - 24 Apr 2024

Wheeler C, Masimirembwa C, Mthembu B, Botha J, Scholefield J, Fabian J

Abstract excerpt

BACKGROUND: In the paediatric liver transplant programme in Johannesburg, South Africa (SA), tacrolimus is the calcineurin inhibitor of choice, comprising an essential component of the immunosuppression regimen. It is characterised by a narrow therapeutic index and wide interpatient variability, necessitating therapeutic drug monitoring of whole-blood concentrations. Pharmacogenetic research, although not...

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Identifiers

PMID: 39041443
DOI: 10.7196/SAMJ.2024.v114i3b.1367

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