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Article

Hepatitis B virus basal core promoter mutations show lower replication fitness associated with cccDNA acetylation status.

Virus research - 15 Jul 2016

Koumbi Lemonica, Pollicino Teresa, Raimondo Giovanni, Stampoulis Dimitrios, Khakoo Salim, Karayiannis Peter

Abstract excerpt

In chronic hepatitis B virus (HBV) infection, variants with mutations in the basal core promoter (BCP) and precore region predominate and associate with more severe disease forms. Studies on their effect on viral replication remain controversial. Increasing evidence shows that epigenetic modifications of cccDNA regulate HBV replication and disease outcome. Here we determined the transcription and viral...

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Topics

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Share to Acetylation
Share to DNA, Circular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferase 1

Share to DNA Replication

Share to Hep G2 Cells

Share to Histone Deacetylase 1

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Share to Methylation

Source

Identifiers

PMID: 27132039
DOI: 10.1016/j.virusres.2016.04.022

Genes

DNMT1
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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