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Mechanism and significance of chromosome damage repair by homologous recombination

5 Aug 2020

Abstract excerpt

Homologous recombination (HR) is a major, conserved pathway of chromosome damage repair. It not only fulfills key functions in the removal of deleterious lesions such as DNA double-strand breaks (DSBs) and interstrand cross-links (ICLs), but also in replication fork repair and protection. Several familial and acquired cancer predisposition syndromes stem from defects in HR. In particular, individuals with...

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PMID: 32756864
DOI: 10.1042/ebc20190093

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