Article
Translational Control of Secretory Proteins in Health and Disease.
International journal of molecular sciences - 6 Apr 2020
Karamyshev Andrey L, Tikhonova Elena B, Karamysheva Zemfira N
Abstract excerpt
Secretory proteins are synthesized in a form of precursors with additional sequences at their N-terminal ends called signal peptides. The signal peptides are recognized co-translationally by signal recognition particle (SRP). This interaction leads to targeting to the endoplasmic reticulum (ER) membrane and translocation of the nascent chains into the ER lumen. It was demonstrated recently that in addition to a...
Topics
- Biological Transport
- Disease Susceptibility
- Gene Expression Regulation
- Homeostasis
- Humans
- Mutation
- Protein Biosynthesis
- Protein Processing, Post-Translational
- RNA, Messenger