Article
A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors.
The Journal of biological chemistry - 10 Jun 2016
Blevitt Jonathan M, Hack Michael D, Herman Krystal, Chang Leon, Keith John M, Mirzadegan Tara, Rao Navin L, Lebsack Alec D, Milla Marcos E
Abstract excerpt
5-Lipoxygenase activating protein (FLAP) plays a critical role in the metabolism of arachidonic acid to leukotriene A4, the precursor to the potent pro-inflammatory mediators leukotriene B4 and leukotriene C4 Studies with small molecule inhibitors of FLAP have led to the discovery of a drug binding pocket on the protein surface, and several pharmaceutical companies have developed compounds and performed clinical...
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