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Article

Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375.

Proceedings of the National Academy of Sciences of the United States of America - 2 Apr 2002

Rudberg Peter C, Tholander Fredrik, Thunnissen Marjolein M G M, Samuelsson Bengt, Haeggstrom Jesper Z

Abstract excerpt

Leukotriene A4 (LTA4, 5S-trans-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid) hydrolase (LTA4H)/aminopeptidase is a bifunctional zinc metalloenzyme that catalyzes the final and rate-limiting step in the biosynthesis of leukotriene B4 (LTB4, 5S,12R-dihydroxy-6,14-cis-8,10-trans-eicosatetraen...

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Identifiers

PMID: 11917124
DOI: 10.1073/pnas.072090099
PMCID: PMC123628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11917124-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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