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Article

Identification of molecular determinants for a potent mammalian TRPA1 antagonist by utilizing species differences.

Journal of molecular neuroscience : MN - 1 Nov 2013

Nakatsuka Kazumasa, Gupta Rupai, Saito Shigeru, Banzawa Nagako, Takahashi Kenji, Tominaga Makoto, Ohta Toshio

Abstract excerpt

The transient receptor potential A1 (TRPA1) receptor is a member of the TRP family and an excitatory nonselective cation channel. An increasing body of evidence suggests that TRPA1 acts as a nociceptor for various chemicals and physical stimuli. Thus, many TRPA1 antagonists have been developed as analgesic agents. Recently, we found that AP18, a mammalian TRPA1 antagonist, does not inhibit heterologously...

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Identifiers

PMID: 23872983
DOI: 10.1007/s12031-013-0060-2

Genes

TRPA1

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Identification of molecular determinants for a potent mammalian TRPA1 antagonist by utilizing species differences.PMID 23872983Read ↗

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