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Article

Inhibition of Ligand-Gated TRPA1 by General Anesthetics.

Molecular pharmacology - 1 Sept 2020

Ton Hoai T, Phan Thieu X, Ahern Gerard P

Abstract excerpt

Several general anesthetics (GAs) produce pain or irritation upon administration, and this occurs predominantly through the activation of the nociceptive ion channel, transient receptor potential ankyrin type 1 (TRPA1). However, the effects of GAs on agonist-mediated TRPA1 activity are unclear. Here we show that a diverse range of noxious and non-noxious volatile anesthetics, at clinically relevant...

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Identifiers

PMID: 32580996
DOI: 10.1124/mol.119.118851
PMCID: PMC7406985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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