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Article

Characterization of novel non-peptide thrombopoietin mimetics, their species specificity and the activation mechanism of the thrombopoietin receptor.

European journal of pharmacology - 31 May 2008

Yamane Noriko, Tanaka Yoshikazu, Ohyabu Naoki, Yamane Shoji, Maekawa Kazuhiko, Ishizaki Jun, Suzuki Ryuji, Itoh Tsunetoshi, Takemoto Hiroshi

Abstract excerpt

A series of non-peptide small compounds discovered to be thrombopoietin receptor agonists showed species specificity to humans. Compound I could induce megakaryocyte lineage from human bone marrow cells, but not from mouse, guinea pig or cynomolgus monkey bone marrow cells. To elucidate the mechanism, we identified the pivotal amino acid residue for the receptor activation by compound I by taking advantage of its...

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PMID: 18377892
DOI: 10.1016/j.ejphar.2008.02.060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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