Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences.

doi:10.1016/j.jsb.2010.03.006

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Article

Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences.

Journal of structural biology - 1 Jul 2010

Dewilde Maarten, Van De Craen Britt, Compernolle Griet, Madsen Jeppe B, Strelkov Sergei, Gils Ann, Declerck Paul J

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1) is a serine protease inhibitor (serpin) that plays an important role in cardiovascular disorders and tumor development. The potential role of PAI-1 as a drug target has been evaluated in various animal models (e.g. mouse and rat). Sensitivity to PAI-1 inhibitory agents varied in different species. To date, absence of PAI-1 structures from species other than human hampers...

Topics

Animals
Binding Sites
Crystallization
Humans
Mice
Models, Molecular
Mutation
Plasminogen Activator Inhibitor 1
Protein Structure, Tertiary
Sequence Alignment
Sequence Analysis, Protein
Serpin E2

Source

Open in PubMed

Identifiers

PMID: 20230900
DOI: 10.1016/j.jsb.2010.03.006

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