Article
Microsatellite polymorphism in the P1 promoter region of the IGF‑1 gene is associated with endometrial cancer.
Molecular medicine reports - 1 Jun 2016
Kwasniewski Wojciech, Gozdzicka-Jozefiak Anna, Wolun-Cholewa Maria, Polak Grzegorz, Sierocinska-Sawa Jadwiga, Kwasniewska Anna, Kotarski Jan
Abstract excerpt
Endometrial carcinoma (EC) is the most common type of gynecological malignancy. Studies have demonstrated that the insulin growth factor (IGF) pathway is implicated in the development of endometrial tumors and that the serum levels of IGF‑1 are affected by estrogen. Most EC cells with high microsatellite instability (MSI‑H) accumulate mutations at a microsatellite sequence in the IGF‑1 gene. The present study...
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