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Article

PYRE insertion within HIV-1 subtype C p6-Gag functions as an ALIX-dependent late domain.

Scientific reports - 11 Jun 2018

Chaturbhuj Devidas, Patil Ajit, Gangakhedkar Raman

Abstract excerpt

ALG-2 interacting protein X (ALIX) links HIV-1 Gag to the components of ESCRT-III. HIV-1 engages the ALIX via its nucleocapsid and LYPXnL motif in p6. Overexpression of ALIX corrects the release defect of PTAP deleted HIV-1 via LYPXnL/ALIX pathway. However, HIV-1 subtype C lacks the LYPXnL motif and hence cannot employ LYPXnL/ALIX mechanism. Though the preferential occurrences of PYXE insertion in HIV-1 C p6 is...

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Identifiers

PMID: 29891975
DOI: 10.1038/s41598-018-27162-1
PMCID: PMC5995805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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PYRE insertion within HIV-1 subtype C p6-Gag functions as an ALIX-dependent late domain.PMID 29891975Read ↗

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