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Article

The C-terminal p6 domain of the HIV-1 Pr55Gag precursor is required for specific binding to the genomic RNA.

RNA biology - 1 Jan 2018

Dubois Noé, Khoo Keith K, Ghossein Shannon, Seissler Tanja, Wolff Philippe, McKinstry William J, Mak Johnson, Paillart Jean-Christophe, Marquet Roland, Bernacchi Serena

Abstract excerpt

The Pr55Gag precursor specifically selects the HIV-1 genomic RNA (gRNA) from a large excess of cellular and partially or fully spliced viral RNAs and drives the virus assembly at the plasma membrane. During these processes, the NC domain of Pr55Gag interacts with the gRNA, while its C-terminal p6 domain binds cellular and viral factors and orchestrates viral particle release. Gag∆p6 is a truncated form of Pr55Gag...

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Identifiers

PMID: 29954247
DOI: 10.1080/15476286.2018.1481696
PMCID: PMC6161697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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