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Article

HIV-1 protease with leucine zipper fused at N-terminus exhibits enhanced linker amino acid-dependent activity.

Retrovirology - 14 Apr 2018

Yu Fu-Hsien, Wang Chin-Tien

Abstract excerpt

BACKGROUND: HIV-1 protease (PR) activation is triggered by Gag-Pol dimerization. Premature PR activation results in reduced virion yields due to enhanced Gag cleavage. A p6* transframe peptide located directly upstream of protease is believed to play a modulating role in PR activation. Previous reports indicate that the C-terminal p6* tetra-peptide prevents premature PR activation triggered by a leucine zipper...

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Share to Enzyme Activation
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29655366
DOI: 10.1186/s12977-018-0413-6
PMCID: PMC5899837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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