Article
Mutational analysis of hepatitis B virus pre-S1 (9-24) fusogenic peptide.
Biochemical and biophysical research communications - 27 May 2016
Liu Qiushi, Somiya Masaharu, Shimada Naohiko, Sakamoto Wakako, Yoshimoto Nobuo, Iijima Masumi, Tatematsu Kenji, Nakai Tadashi, Okajima Toshihide, Maruyama Atsushi, Kuroda Shuńichi
Abstract excerpt
A hollow nanoparticle known as a bio-nanocapsule (BNC) consisting of hepatitis B virus (HBV) envelope L protein and liposome (LP) can encapsulate drugs and genes and thereby deliver them in vitro and in vivo to human hepatic tissues, specifically by utilizing the HBV-derived infection machinery. Recently, we identified a low pH-dependent fusogenic domain at the N-terminal part of the pre-S1 region of the HBV L...
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