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Article

Mutation of arginine residues to avoid non-specific cellular uptakes for hepatitis B virus core particles.

Journal of nanobiotechnology - 13 Feb 2015

Bin Mohamed Suffian Izzat Fahimuddin, Nishimura Yuya, Morita Kenta, Nakamura-Tsuruta Sachiko, Al-Jamal Khuloud T, Ishii Jun, Ogino Chiaki, Kondo Akihiko

Abstract excerpt

BACKGROUND: The hepatitis B virus core (HBc) particle is known as a promising new carrier for the delivery of drugs and nucleic acids. However, since the arginine-rich domain that is located in the C-terminal region of the HBc monomer binds to the heparan sulphate proteoglycan on the cell surface due to its positive charge, HBc particles are introduced non-specifically into a wide range of cells. To avoid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25890025
DOI: 10.1186/s12951-015-0074-8
PMCID: PMC4334417

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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