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Article

Effective Therapeutic Drug Delivery by GALA3, an Endosomal Escape Peptide with Reduced Hydrophobicity.

The Journal of membrane biology - 1 Apr 2020

Li Chen, Cao Xue-Wei, Zhao Jian, Wang Fu-Jun

Abstract excerpt

Endosomal escape is a rate-limiting step in the cytosolic delivery of therapeutic drugs. Overcoming this barrier is crucial to achieve an effective biological based therapy. In this work, we evaluated the ability of a synthetic biomimetic peptide derived from the GALA to facilitate endosomal escape of protein drugs. Our results showed that the cytoplasmic distribution of GALA fusion proteins changed according to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32002589
DOI: 10.1007/s00232-020-00109-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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