Article
γ-Amino acid mutated α-coiled coils as mild thermal triggers for liposome delivery.
Chemical communications (Cambridge, England) - 7 Dec 2013
Jadhav Sandip V, Singh Sumeet K, Reja Rahi M, Gopi Hosahudya N
Abstract excerpt
The stability and compatibility of designed coiled coil peptides towards the selective incorporation of γ(4)-amino acids at the hydrophobic positions of the heptad repeat are studied. Investigations reveal that the low thermal denaturation temperature of γ(4)-residue mutated coiled coils can be utilized as a mild hyperthermia trigger in liposomes.
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