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Article

A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction.

Brain : a journal of neurology - 1 Apr 2017

Lopez Ana, Lee Suzee E, Wojta Kevin, Ramos Eliana Marisa, Klein Eric, Chen Jason, Boxer Adam L, Gorno-Tempini Maria Luisa, Geschwind Daniel H, Schlotawa Lars, Ogryzko Nikolay V, Bigio Eileen H, Rogalski Emily, Weintraub Sandra, Mesulam Marsel M, Fleming Angeleen, Coppola Giovanni, Miller Bruce L, Rubinsztein David C

Abstract excerpt

Mutations in the gene encoding tau (MAPT) cause frontotemporal dementia spectrum disorders. A rare tau variant p.A152T was reported as a risk factor for frontotemporal dementia spectrum and Alzheimer's disease in an initial case-control study. Such findings need replication in an independent cohort. We analysed an independent multinational cohort comprising 3100 patients with neurodegenerative disease and 4351...

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Identifiers

PMID: 28334843
DOI: 10.1093/brain/awx005
PMCID: PMC5382950

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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