Article
Association of human leukocyte antigen class II genes with autoantibody profiles, but not with disease susceptibility in Japanese patients with systemic sclerosis.
Internal medicine (Tokyo, Japan) - 1 Apr 1999
Kuwana M, Inoko H, Kameda H, Nojima T, Sato S, Nakamura K, Ogasawara T, Hirakata M, Ohosone Y, Kaburaki J, Okano Y, Mimori T
Abstract excerpt
OBJECT: To examine the role of human leukocyte antigen (HLA) class II genes in the development of systemic sclerosis (SSc) as well as in the clinical and serologic expression of SSc in patients. METHODS: HLA-DRB1, DRB3, DRB4, DQB1, and DPB1 alleles were determined by genotyping; and serum antinuclear antibodies were identified using indirect immunofluorescence, double immunodiffusion and immunoprecipitation....
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