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Association of HLA-DRB115:02:01, DQB105:01:24 and DPB1*13:01:01 in Thai patients with systemic sclerosis.

HLA - 1 Dec 2022

Louthrenoo Worawit, Kasitanon Nuntana, Wongthanee Antika, Okudaira Yuko, Takeuchi Masumi, Nakajima Fumiaki, Habata Miwa, Masuya Anri, Noguchi Hiroshi, Inoko Hidetoshi, Takeuchi Fujio

Abstract excerpt

HLA studies in patients with systemic sclerosis (SSc) have shown variable results. This study aimed to examine the association of HLA class I and II risk alleles in Thai SSc patients, and clarify the contribution of risk HLA alleles to the pathogenesis and clinical manifestations. Blood samples from 92 SSc patients and 135 healthy controls (HCs) were collected. Eleven loci of the HLA class I (HLA-A, B, and C) and...

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PMID: 36054790
DOI: 10.1111/tan.14793

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