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HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans.

Arthritis and rheumatism - 1 Dec 2009

Zhou Xiaodong, Lee Jong Eun, Arnett Frank C, Xiong Momiao, Park Min Young, Yoo Yeon Kyeong, Shin Eun Soon, Reveille John D, Mayes Maureen D, Kim Jin Hyun, Song Ran, Choi Ji Yong, Park Ji Ah, Lee Yun Jong, Lee Eun Young, Song Yeong Wook, Lee Eun Bong

Abstract excerpt

OBJECTIVE: To identify systemic sclerosis (SSc) susceptibility loci via a genome-wide association study. METHODS: A genome-wide association study was performed in 137 patients with SSc and 564 controls from Korea using the Affymetrix Human SNP Array 5.0. After fine-mapping studies, the results were replicated in 1,107 SSc patients and 2,747 controls from a US Caucasian population. RESULTS: The single-nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19950302
DOI: 10.1002/art.24982
PMCID: PMC2829245

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