Article

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats

2025-07-18

Abstract excerpt

<h4>Background</h4> Cocaine use disorder (CUD) is a major public health crisis with detrimental individual and societal effects. The specific genes mediating CUD remain largely unknown. <h4>Methods</h4> We conducted a genome-wide association study (GWAS) using outbred N/NIH Heterogeneous Stock (HS; n = 836, female = 415, male = 421) rats. We examined multiple CUD-related phenotypes that captured acquisition of s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c989d02a-ef9a-5810-8887-5ea015c7f620
DOI: 10.1101/2025.07.17.660811

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock ratsDOI 10.1101/2025.07.17.660811Read

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats.Semantic proximity Read

Molecular genetics of cocaine use disorders in humansSemantic proximity Read

Genome-wide association study in Heterogeneous Stock rats identifies genetic loci associated with aversion-based learning and cocaine aversionSemantic proximity Read

Extreme phenotypic diversity in operant response to intravenous cocaine or saline infusion in the hybrid mouse diversity panel.Semantic proximity Read

Spontaneously Hypertensive Rat substrains show differences in model traits for addiction risk and cocaine self-administration: Implications for a novel rat reduced complexity cross.Semantic proximity Read

A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interactionSemantic proximity Read

Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations.Semantic proximity Read

The collaborative cross strains and their founders vary widely in cocaine-induced behavioral sensitizationSemantic proximity Read

The Collaborative Cross strains and their founders vary widely in cocaine-induced behavioral sensitizationSemantic proximity Read

Environmental, genetic and epigenetic contributions to cocaine addiction.Semantic proximity Read

Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM-IV cocaine dependence as traits for genetic association analysis.Semantic proximity Read

Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics.Semantic proximity Read