Article

Cocaine during adolescence differentially impacts psychomotor sensitization and epigenetic profiles in adult male rats with divergent affective phenotypes

2022-07-14

Abstract excerpt

While early life drug use reliably predicts addiction liability in adulthood, the molecular mechanism by which this occurs, and the degree genetic predisposition is involved is not known. We used a unique genetic rat model of temperament to determine the impact of adolescent cocaine experience on adult psychomotor sensitization and epigenetic profiles in the striatum. Relative to adult bred low-responder (bLR) rat...

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Literature Corpus work: 1a25a271-2b1b-5476-9885-68035d547728
DOI: 10.1101/2022.07.13.499935

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Cocaine during adolescence differentially impacts psychomotor sensitization and epigenetic profiles in adult male rats with divergent affective phenotypesDOI 10.1101/2022.07.13.499935Read

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