Article
Limited Polymorphism of the Kelch Propeller Domain in Plasmodium malariae and P. ovale Isolates from Thailand.
Antimicrobial agents and chemotherapy - 1 Jul 2016
Nakeesathit Supatchara, Saralamba Naowarat, Pukrittayakamee Sasithon, Dondorp Arjen, Nosten Francois, White Nicholas J, Imwong Mallika
Abstract excerpt
Artemisinin resistance in Plasmodium falciparum, the agent of severe malaria, is currently a major obstacle to malaria control in Southeast Asia. A gene named "kelch13" has been associated with artemisinin resistance in P. falciparum The orthologue of the kelch gene in P. vivax was identified and a small number of mutations were found in previous studies. The kelch orthologues in the other two human malaria...
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