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Reduced Polymorphism in the Kelch Propeller Domain in Plasmodium vivax Isolates from Cambodia

11 Nov 2014

Abstract excerpt

Polymorphism in the ortholog gene of the Plasmodium falciparum K13 gene was investigated in Plasmodium vivax isolates collected in Cambodia. All of them were Sal-1 wild-type alleles except two (2/284, 0.7%), and P. vivax K12 polymorphism was reduced compared to that of the P. falciparum K13 gene. Both mutant allele isolates had the same nonsynonymous mutation at codon 552 (V552I) and were from Ratanak Kiri...

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PMID: 25385109
DOI: 10.1128/aac.03908-14

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