Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jan 2010

Wu Tao, Merbl Yifat, Huo Ying, Gallop Jennifer L, Tzur Amit, Kirschner Marc W

Abstract excerpt

The Anaphase-Promoting Complex (APC) is an E3 ubiquitin ligase that regulates mitosis and G1 by sequentially targeting cell-cycle regulators for ubiquitination and proteasomal degradation. The mechanism of ubiquitin chain formation by APC and the resultant chain topology remains controversial. By using a single-lysine APC substrate to dissect the topology of ubiquitinated substrates, we find that APC-catalyzed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase-Promoting Complex-Cyclosome
Share to Biocatalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle

Share to Lysine

Share to Securin

Share to Ubiquitin

Share to Ubiquitin-Conjugating Enzymes

Share to Ubiquitin-Protein Ligase Complexes

Source

Open in PubMed Open full text

Identifiers

PMID: 20080579
DOI: 10.1073/pnas.0912802107
PMCID: PMC2802591

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.PMID 20080579Read ↗

Emerging regulatory mechanisms in ubiquitin-dependent cell cycle controlSemantic proximity Read ↗

Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.Semantic proximity Read ↗

Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)Semantic proximity Read ↗

Large-scale PTM analysis reveals that the E3 ligase, Anaphase promoting complex, APC/C, is a master regulator of protein complexes containing GIGYF2.Semantic proximity Read ↗

Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48‐linked ubiquitin chainsSemantic proximity Read ↗

Cyclin-dependent kinase 1-dependent activation of APC/C ubiquitin ligase.Semantic proximity Read ↗

Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase.Semantic proximity Read ↗

RING E3-Catalyzed E2 Self-Ubiquitination Attenuates the Activity of Ube2E Ubiquitin-Conjugating Enzymes.Semantic proximity Read ↗

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.Semantic proximity Read ↗

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.Semantic proximity Read ↗

The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K.Semantic proximity Read ↗

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.