Article

Ubiquitin in Cell-Cycle Regulation and Dysregulation in Cancer

2017-03-06

Abstract excerpt

Uncontrolled cell proliferation and genomic instability are common features of cancer and can arise from, respectively, the loss of cell-cycle control and defective checkpoints. Ubiquitin-mediated proteolysis, ultimately executed by ubiquitin-ligating enzymes (E3s), plays a key part in cell-cycle regulation and is dominated by two multisubunit E3s, the anaphase-promoting complex (or cyclosome) (APC/C) and SKP1–cul...

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Literature Corpus work: 9982d4c1-0cec-59f7-9fa9-2154f56e12e2
DOI: 10.1146/annurev-cancerbio-040716-075607

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