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Article

Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)

1 Nov 2017

Abstract excerpt

The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators. During the two decades since its discovery, much has been learnt concerning its role in recognizing and ubiquitinating specific proteins in a cell-cycle-dependent manner, the mechanisms governing substrate...

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PMID: 29167309
DOI: 10.1098/rsob.170204

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