Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells.

Bone - 1 Jul 2016

Collette Nicole M, Yee Cristal S, Hum Nicholas R, Murugesh Deepa K, Christiansen Blaine A, Xie LiQin, Economides Aris N, Manilay Jennifer O, Robling Alexander G, Loots Gabriela G

Abstract excerpt

Loss of Sostdc1, a growth factor paralogous to Sost, causes the formation of ectopic incisors, fused molars, abnormal hair follicles, and resistance to kidney disease. Sostdc1 is expressed in the periosteum, a source of osteoblasts, fibroblasts and mesenchymal progenitor cells, which are critically important for fracture repair. Here, we investigated the role of Sostdc1 in bone metabolism and fracture repair....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomechanical Phenomena
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcification, Physiologic

Share to Nestin

Share to Osteogenesis

Share to Wnt Signaling Pathway

Share to X-Ray Microtomography

Source

Open in PubMed Open full text

Identifiers

PMID: 27102547
DOI: 10.1016/j.bone.2016.04.005
PMCID: PMC6277141

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells.PMID 27102547Read ↗

Role of Sostdc1 in skeletal biology and cancerSemantic proximity Read ↗

Generation of Two Multipotent Mesenchymal Progenitor Cell Lines Capable of Osteogenic, Mature Osteocyte, Adipogenic, and Chondrogenic DifferentiationSemantic proximity Read ↗

A multi-stem cell basis for craniosynostosis and calvarial mineralization.Semantic proximity Read ↗

A multi-stem cell basis for craniosynostosis and calvarial mineralizationSemantic proximity Read ↗

Loss of Signal Transducer and Activator of Transcription 3 Impaired the Osteogenesis of Mesenchymal Progenitor Cells in Vivo and in VitroSemantic proximity Read ↗

Generation of two Multipotent Mesenchymal Progenitor Cell Lines Capable of Osteogenic, Mature Osteocyte, Adipogenic, and Chondrogenic DifferentiationSemantic proximity Read ↗

Loss of signal transducer and activator of transcription 3 impaired the osteogenesis of mesenchymal progenitor cells in vivo and in vitroSemantic proximity Read ↗

Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivoSemantic proximity Read ↗

Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development.Semantic proximity Read ↗

Mef2c deletion in osteocytes results in increased bone mass.Semantic proximity Read ↗

The Dmp1-SOST Transgene Interacts With and Downregulates the Dmp1-Cre Transgene and the Rosa(Notch) Allele.Semantic proximity Read ↗

Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.