Article
A multi-stem cell basis for craniosynostosis and calvarial mineralization.
Nature - 1 Sept 2023
Bok Seoyeon, Yallowitz Alisha R, Sun Jun, McCormick Jason, Cung Michelle, Hu Lingling, Lalani Sarfaraz, Li Zan, Sosa Branden R, Baumgartner Tomas, Byrne Paul, Zhang Tuo, Morse Kyle W, Mohamed Fatma F, Ge Chunxi, Franceschi Renny T, Cowling Randy T, Greenberg Barry H, Pisapia David J, Imahiyerobo Thomas A, Lakhani Shenela, Ross M Elizabeth, Hoffman Caitlin E, Debnath Shawon, Greenblatt Matthew B
Abstract excerpt
Craniosynostosis is a group of disorders of premature calvarial suture fusion. The identity of the calvarial stem cells (CSCs) that produce fusion-driving osteoblasts in craniosynostosis remains poorly understood. Here we show that both physiologic calvarial mineralization and pathologic calvarial fusion in craniosynostosis reflect the interaction of two separate stem cell lineages; a previously identified...
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