Back to search

Article

A multi-stem cell basis for craniosynostosis and calvarial mineralization

2021-11-30

Abstract excerpt

<title>Abstract</title> <p>Craniosynostosis is a group of disorders of premature calvarial sutural fusion. An incomplete understanding of the calvarial stem cells (CSCs) that produce fusion-driving osteoblasts has limited the development of non-surgical therapeutic approaches for craniosynostosis. Here we show that both physiologic calvarial mineralization and pathologic calvarial fusion in craniosynostosis refle...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9ab8e267-af26-5d36-a329-edc23cd0d10c
DOI
10.21203/rs.3.rs-1061838/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A multi-stem cell basis for craniosynostosis and calvarial mineralizationDOI 10.21203/rs.3.rs-1061838/v1
A multi-stem cell basis for craniosynostosis and calvarial mineralization.Semantic proximity
Tyrosine kinase receptor c-ros-oncogene 1 inhibition alleviates aberrant bone formation of TWIST-1 haploinsufficient calvarial cells from Saethre-Chotzen syndrome patients.Semantic proximity
The clinical manifestations, molecular mechanisms and treatment of craniosynostosis.Semantic proximity
Mesodermal expression of Fgfr2S252W is necessary and sufficient to induce craniosynostosis in a mouse model of Apert syndrome.Semantic proximity
Insights into the development of molecular therapies for craniosynostosis.Semantic proximity
Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies.Semantic proximity
Molecular and cellular bases of syndromic craniosynostoses.Semantic proximity
Roles of FGFR2 and twist in human craniosynostosis: insights from genetic mutations in cranial osteoblasts.Semantic proximity
Understanding craniosynostosis as a growth disorder.Semantic proximity
Molecular Mechanisms Involved in Craniosynostosis.Semantic proximity
The developing mouse coronal suture at single-cell resolutionSemantic proximity
Stem cells of the suture mesenchyme in craniofacial bone development, repair and regenerationSemantic proximity
Select a neighboring publication to make it the new centre.