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Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice

3 May 2010

Abstract excerpt

During skeletal development and regeneration, bone-forming osteoblasts respond to high metabolic demand by active expansion of their rough endoplasmic reticulum (rER) and increased synthesis of type I collagen, the predominant bone matrix protein. However, the molecular mechanisms that orchestrate this response are not well understood. We show that insertional mutagenesis of the previously uncharacterized...

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PMID: 20440000
DOI: 10.1083/jcb.201003006

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