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Article

Role of Sostdc1 in skeletal biology and cancer

21 Oct 2022

Abstract excerpt

Sclerostin domain-containing protein-1 (Sostdc1) is a member of the sclerostin family and encodes a secreted 28-32 kDa protein with a cystine knot-like domain and two N-linked glycosylation sites. Sostdc1 functions as an antagonist to bone morphogenetic protein (BMP), mediating BMP signaling. It also interacts with LRP6, mediating LRP6 and Wnt signaling, thus regulating cellular proliferation, differentiation,...

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Identifiers

PMID: 36338475
DOI: 10.3389/fphys.2022.1029646

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