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Article

Investigating the WNT and TGF-beta pathways alterations and tumor mutant burden in young-onset colorectal cancer.

Scientific reports - 2 Aug 2024

Ferrell Morgan, Guven Deniz Can, Gomez Cyndi Gonzalez, Nasrollahi Elham, Giza Richard, Cheng Svea, Syed Masood Pasha, Magge Tara, Singhi Aatur, Saeed Anwaar, Saridogan Turcin, Sahin Ibrahim Halil

Abstract excerpt

Colorectal cancer (CRC) is the third most common cancer in the United States. Recent epidemiological evidence demonstrates an increasing incidence of young-onset CRC cases, defined as CRC cases in individuals 50 years old or younger. Studies have established that alterations in both the WNT and TGF-Beta signaling pathways have contributed to CRC development. While this is well understood, the comprehensive...

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Identifiers

PMID: 39095553
DOI: 10.1038/s41598-024-68938-y
PMCID: PMC11297303

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