Energy efficiency trade-offs drive nucleotide usage in transcribed regions.

doi:10.1038/ncomms11334

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Article

Energy efficiency trade-offs drive nucleotide usage in transcribed regions.

Nature communications - 21 Apr 2016

Chen Wei-Hua, Lu Guanting, Bork Peer, Hu Songnian, Lercher Martin J

Abstract excerpt

Efficient nutrient usage is a trait under universal selection. A substantial part of cellular resources is spent on making nucleotides. We thus expect preferential use of cheaper nucleotides especially in transcribed sequences, which are often amplified thousand-fold compared with genomic sequences. To test this hypothesis, we derive a mutation-selection-drift equilibrium model for nucleotide skews...

Topics

Amino Acids
Bacteria
Base Composition
Base Pairing
Biological Evolution
Codon
Genome, Bacterial
Models, Genetic
Mutation
Nucleotides
Operon
Protein Biosynthesis
Selection, Genetic
Thermodynamics
Transcription, Genetic

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Identifiers

PMID: 27098217
DOI: 10.1038/ncomms11334
PMCID: PMC4844684

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