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Article

Energy efficiency trade-offs drive nucleotide usage in transcribed regions.

Nature communications - 21 Apr 2016

Chen Wei-Hua, Lu Guanting, Bork Peer, Hu Songnian, Lercher Martin J

Abstract excerpt

Efficient nutrient usage is a trait under universal selection. A substantial part of cellular resources is spent on making nucleotides. We thus expect preferential use of cheaper nucleotides especially in transcribed sequences, which are often amplified thousand-fold compared with genomic sequences. To test this hypothesis, we derive a mutation-selection-drift equilibrium model for nucleotide skews...

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PMID: 27098217
DOI: 10.1038/ncomms11334
PMCID: PMC4844684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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