Article
The fundamental tradeoff in genomes and proteomes of prokaryotes established by the genetic code, codon entropy, and physics of nucleic acids and proteins.
Biology direct - 12 Dec 2014
Goncearenco Alexander, Berezovsky Igor N
Abstract excerpt
BACKGROUND: Mutations in nucleotide sequences provide a foundation for genetic variability, and selection is the driving force of the evolution and molecular adaptation. Despite considerable progress in the understanding of selective forces and their compositional determinants, the very nature of underlying mutational biases remains unclear. RESULTS: We explore here a fundamental tradeoff, which analytically...
Topics
- Archaea
- Bacteria
- Base Composition
- Codon
- Entropy
- Genetic Code
- Genome
- Models, Genetic
- Mutation
- Proteome