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Article

Synonymous codon bias and functional constraint on GC3-related DNA backbone dynamics in the prokaryotic nucleoid.

Nucleic acids research - 1 Jan 2014

Babbitt Gregory A, Alawad Mohammed A, Schulze Katharina V, Hudson André O

Abstract excerpt

While mRNA stability has been demonstrated to control rates of translation, generating both global and local synonymous codon biases in many unicellular organisms, this explanation cannot adequately explain why codon bias strongly tracks neighboring intergene GC content; suggesting that structural dynamics of DNA might also influence codon choice. Because minor groove width is highly governed by 3-base...

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Identifiers

PMID: 25200075
DOI: 10.1093/nar/gku811
PMCID: PMC4176184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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