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Article

A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes.

Genome biology - 1 Jan 2001

Knight R D, Freeland S J, Landweber L F

Abstract excerpt

BACKGROUND: Correlations between genome composition (in terms of GC content) and usage of particular codons and amino acids have been widely reported, but poorly explained. We show here that a simple model of processes acting at the nucleotide level explains codon usage across a large sample of species (311 bacteria, 28 archaea and 257 eukaryotes). The model quantitatively predicts responses (slope and intercept...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11305938
DOI: 10.1186/gb-2001-2-4-research0010
PMCID: PMC31479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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