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Article

Combining structure probing data on RNA mutants with evolutionary information reveals RNA-binding interfaces.

Nucleic acids research - 20 Jun 2016

Reinharz Vladimir, Ponty Yann, Waldispühl Jérôme

Abstract excerpt

Systematic structure probing experiments (e.g. SHAPE) of RNA mutants such as the mutate-and-map (MaM) protocol give us a direct access into the genetic robustness of ncRNA structures. Comparative studies of homologous sequences provide a distinct, yet complementary, approach to analyze structural and functional properties of non-coding RNAs. In this paper, we introduce a formal framework to combine the...

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PMID: 27095200
DOI: 10.1093/nar/gkw217
PMCID: PMC4914100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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