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Article

Natural and artificial RNAs occupy the same restricted region of sequence space.

RNA (New York, N.Y.) - 1 Feb 2010

Kennedy Ryan, Lladser Manuel E, Wu Zhiyuan, Zhang Chen, Yarus Michael, De Sterck Hans, Knight Rob

Abstract excerpt

Different chemical and mutational processes within genomes give rise to sequences with different compositions and perhaps different capacities for evolution. The evolution of functional RNAs may occur on a "neutral network" in which sequences with any given function can easily mutate to sequences with any other. This neutral network hypothesis is more likely if there is a particular region of composition that...

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Identifiers

PMID: 20032164
DOI: 10.1261/rna.1923210
PMCID: PMC2811657

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