Article
MIMEAnTo: profiling functional RNA in mutational interference mapping experiments.
Bioinformatics (Oxford, England) - 1 Nov 2016
Smith Maureen R, Smyth Redmond P, Marquet Roland, von Kleist Max
Abstract excerpt
The mutational interference mapping experiment (MIME) is a powerful method that, coupled to a bioinformatics analysis pipeline, allows the identification of domains and structures in RNA that are important for its function. In MIME, target RNAs are randomly mutated, selected by function, physically separated and sequenced using next-generation sequencing (NGS). Quantitative effects of each mutation at each...
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