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Article

NLRP3 Localizes to the Tubular Epithelium in Human Kidney and Correlates With Outcome in IgA Nephropathy.

Scientific reports - 20 Apr 2016

Chun Justin, Chung Hyunjae, Wang Xiangyu, Barry Rebecca, Taheri Zohreh Mohammad, Platnich Jaye M, Ahmed Sofia B, Trpkov Kiril, Hemmelgarn Brenda, Benediktsson Hallgrimur, James Matthew T, Muruve Daniel A

Abstract excerpt

Nod-like receptor pyrin domain-containing-3 (NLRP3) has been implicated in the pathogenesis of experimental renal injury, yet its characterization in human kidney disease remains largely unexplored. NLRP3 expression was evaluated in human kidney biopsies, primary renal tubular cells (HPTC) and correlated to disease outcomes in patients with IgA nephropathy (IgAN). NLRP3 localized to renal tubules in normal human...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 27093923
DOI: 10.1038/srep24667
PMCID: PMC4837396

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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