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Article

Mitochondrial dysfunction confers albumin-induced NLRP3 inflammasome activation and renal tubular injury.

American journal of physiology. Renal physiology - 15 Apr 2015

Zhuang Yibo, Yasinta Marchella, Hu Caiyu, Zhao Min, Ding Guixia, Bai Mi, Yang Lingyun, Ni Jiajia, Wang Rong, Jia Zhanjun, Huang Songming, Zhang Aihua

Abstract excerpt

Proteinuria is involved in the development of tubular lesions and in the progressive loss of renal function in chronic kidney diseases via uncertain mechanisms. Growing evidence suggests a pathogenic role of mitochondrial dysfunction in chronic kidney diseases. Therefore, the present study aimed to define the roles of mitochondria in proteinuria-induced renal tubular injury and their underlying mechanisms. Using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25694478
DOI: 10.1152/ajprenal.00203.2014

Genes

NLRP3
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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