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Article

Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells.

Experimental & molecular medicine - 1 May 2022

Fan Liang-Liang, Du Ran, Liu Ji-Shi, Jin Jie-Yuan, Wang Chen-Yu, Dong Yi, He Wan-Xia, Yan Ri-Qiang, Xiang Rong

Abstract excerpt

Reticulon 3 (RTN3) is an endoplasmic reticulum protein that has previously been shown to play roles in neurodegenerative diseases, but little is known about its function in the kidneys. The aim of the present study was to clarify the roles of RTN3 in chronic kidney disease (CKD) and kidney fibrosis. In this study, RTN3 levels were measured in kidney tissues from healthy controls and CKD or kidney fibrosis...

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Identifiers

PMID: 35596061
DOI: 10.1038/s12276-022-00763-7
PMCID: PMC9166791

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