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Article

Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span

23 Jul 2023

Abstract excerpt

The decrease in the podocyte's lifespan and health-span that typify healthy kidney aging cause a decrease in their normal structure, physiology and function. The ability to halt and even reverse these changes becomes clinically relevant when disease is superimposed on an aged kidney. RNA-sequencing of podocytes from middle-aged mice showed an inflammatory phenotype with increases in the NLRP3 inflammasome,...

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Share to Adolescent and Pediatric Healthcare
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Share to Renal Diseases and Glomerulopathies

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Identifiers

PMID: 37487005
DOI: 10.18632/aging.204897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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