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Article

NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy.

Kidney international - 1 Nov 2013

Knauf Felix, Asplin John R, Granja Ignacio, Schmidt Insa M, Moeckel Gilbert W, David Rachel J, Flavell Richard A, Aronson Peter S

Abstract excerpt

Oxalate nephropathy with renal failure is caused by multiple disorders leading to hyperoxaluria due to either overproduction of oxalate (primary hyperoxaluria) or excessive absorption of dietary oxalate (enteric hyperoxaluria). To study the etiology of renal failure in crystal-induced kidney disease, we created a model of progressive oxalate nephropathy by feeding mice a diet high in soluble oxalate (high oxalate...

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Identifiers

PMID: 23739234
DOI: 10.1038/ki.2013.207
PMCID: PMC3772982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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