Article
The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1-mediated tissue injury.
Kidney international - 1 Mar 2018
Anders Hans-Joachim, Suarez-Alvarez Beatriz, Grigorescu Melissa, Foresto-Neto Orestes, Steiger Stefanie, Desai Jyaysi, Marschner Julian A, Honarpisheh Mohsen, Shi Chongxu, Jordan Jutta, Müller Lisa, Burzlaff Nicolai, Bäuerle Tobias, Mulay Shrikant R
Abstract excerpt
Primary/secondary hyperoxalurias involve nephrocalcinosis-related chronic kidney disease (CKD) leading to end-stage kidney disease. Mechanistically, intrarenal calcium oxalate crystal deposition is thought to elicit inflammation, tubular injury and atrophy, involving the NLRP3 inflammasome. Here, we found that mice deficient in NLRP3 and ASC adaptor protein failed to develop nephrocalcinosis, compromising...
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