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The Role of Notch3 Signaling in Kidney Disease

22 Oct 2020

Abstract excerpt

Notch receptors are transmembrane proteins that are members of the epidermal growth factor-like family. These receptors are widely expressed on the cell surface and are highly conserved. Binding to ligands on adjacent cells results in cleavage of these receptors, and their intracellular domains translocate into the nucleus, where target gene transcription is initiated. In the mammalian kidney, Notch receptors are...

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PMID: 33149805
DOI: 10.1155/2020/1809408

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