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Article

Differential innate immune cell signatures and effects regulated by toll-like receptor 4 during murine lung tumor promotion.

Experimental lung research - 1 Apr 2016

Alexander Carla-Maria, Xiong Ka-Na, Velmurugan Kalpana, Xiong Julie, Osgood Ross S, Bauer Alison K

Abstract excerpt

Tumor promotion is an early and critical stage during lung adenocarcinoma (ADC). We previously demonstrated that Tlr4 mutant mice were more susceptible to butylated hydroxytoluene (BHT)-induced pulmonary inflammation and tumor promotion in comparison to Tlr4-sufficient mice. Our study objective was to elucidate the underlying differences in Tlr4 mutant mice in innate immune cell populations, their functional...

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Identifiers

PMID: 27093379
DOI: 10.3109/01902148.2016.1164263
PMCID: PMC5506691

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